Protein Family Models

The outer membrane protein LpxR from Salmonella typhimurium is a lipid A deacylase that catalyses the removal of the 3'-acyloxyacyl moiety from lipid A. This protein folds into a 12-stranded antiparallel beta-barrel with the N- and C- terminal ends pointing towards the periplasm and three extracellular loops consisting of alpha-helical regions at the opposite side of the beta-barrel [1]. [1]. 19174515. Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Rutten L, Mannie JP, Stead CM, Raetz CR, Reynolds CM, Bonvin AM, Tommassen JP, Egmond MR, Trent MS, Gros P;. Proc Natl Acad Sci U S A. 2009;106:1960-1964. (from Pfam)

Date:

2024-10-16

lipid A deacylase LpxR family protein similar to Salmonella typhimurium outer-membrane protein LpxR, a lipid A deacylase that removes the 3'-acyloxyacyl moiety of lipid A

Date:

2018-06-19