Protein Family Models

This family is distantly related to Pfam:PF00062. Members are found in phages, type II, type III and type IV secretion systems (reviewed in [4]). [1]. 8203016. A conserved domain in putative bacterial and bacteriophage transglycosylases. Koonin EV, Rudd KE;. Trends Biochem Sci 1994;19:106-107. [2]. 8692991. A family of lysozyme-like virulence factors in bacterial pathogens of plants and animals. Mushegian AR, Fullner KJ, Koonin EV, Nester EW;. Proc Natl Acad Sci U S A 1996;93:7321-7326. [3]. 7548026. Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism. Thunnissen AM, Rozeboom HJ, Kalk KH, Dijkstra BW;. Biochemistry 1995;34:12729-12737. [4]. 14625683. Lytic transglycosylases in macromolecular transport systems of Gram-negative bacteria. Koraimann G;. Cell Mol Life Sci 2003;60:2371-2388. (from Pfam)

Date:

2024-10-16

This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1]. [1]. 34424339. A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators. Matilla MA, Velando F, Martin-Mora D, Monteagudo-Cascales E, Krell T;. FEMS Microbiol Rev. 2022;46:fuab043. (from Pfam)

Date:

2024-10-16

membrane-bound lytic murein transglycosylase F (MltF) cleaves the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin to allow for the regular growth and maintenance of the murein sacculus

Date:

2023-03-21

Gene:

mltF

Date:

2021-08-12