Protein Family Models

The YjgF/YER057c/UK114 family, including a member protein that has been called endoribonuclease L-PSP (perchloric acid-soluble protein), is now called the RidA family, or more generally the Rid family, with subfamilies RidA and Rid1 through Rid7. YjgF from Salmonella enterica deaminates the toxic metabolite 2-amino acrylate and so was renamed RidA (reactive intermediate imine deaminase A). This HMM hits proteins that are members of multiple Rid subfamilies.

Date:

2024-10-16

Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. Some members of this family are designated RidA and are designated 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10). For other paralogs, specific activities are less clear. Historically, this protein has been called an inhibitor of protein synthesis initiation, then endoribonuclease L-PSP active on single-stranded mRNA, but citations to those reports are now removed from this HMM.

Date:

2021-04-27