Protein Family Models

This region encompasses much of the RNA and SrmB binding motifs on polymerase A. [1]. 10361280. Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation. Raynal LC, Carpousis AJ;. Mol Microbiol. 1999;32:765-775. (from Pfam)

Date:

2024-10-16

HD domains are metal dependent phosphohydrolases. [1]. 9868367. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:469-472. (from Pfam)

Date:

2024-10-16

This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily. [1]. 1438224. Identification of the gene for an Escherichia coli poly(A) polymerase. Cao GJ, Sarkar N;. Proc Natl Acad Sci U S A 1992;89:10380-10384. (from Pfam)

Date:

2024-10-16

multifunctional CCA addition/repair protein catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template

Date:

2023-03-16

Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases

Date:

2021-07-29