Protein Family Models for Protein (Select 446622726) - Protein Family Models

Select item 4223111.

This domain lies at the C-terminus of primase proteins carrying the TOPRIM, Pfam:PF01751, domain. The exact function of the domain is not known. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024727.5
Method:: HMM

Select item 4124482.

toprim domain-containing protein

This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks. [1]. 9722641. Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Aravind L, Leipe DD, Koonin EV;. Nucleic Acids Res 1998;26:4205-4213. [2]. 9224947. Cloning and analysis of the dnaG gene encoding Pseudomonas putida DNA primase. Szafranski P, Smith CL, Cantor CR;. Biochim Biophys Acta 1997;1352:243-248. [3]. 8294018. The Haemophilus influenzae dnaG sequence and conserved bacterial primase motifs. Versalovic J, Lupski JR;. Gene 1993;136:281-286. [4]. 9121560. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Bergerat A, de Massy B, Gadelle D, Varoutas PC, Nicolas A, Forterre P;. Nature 1997;386:414-417. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013878.5
Method:: HMM

Select item 4015553.

new record, indexing in progress

Family Accession:

Select item 3890324.

new record, indexing in progress

Family Accession:

Select item 3569535.

new record, indexing in progress

Family Accession:

Select item 3483846.

new record, indexing in progress

Family Accession:

Select item 1757517.

toprim domain-containing protein

toprim (topoisomerase-primase) domain-containing protein similar to Bacillus subtilis protein YusF

Date:: 2020-11-06

Family Accession:: 10004131
Method:: Sparcle

Select item 188388.

ribonuclease M5

Ribonuclease M5, a toprim family member, is the 5S rRNA maturase in low GC bacterial lineages such as Staphylococcus, Streptococcus, and Bacillus.

Gene:: rnmV

GO Terms:

Biological Process:: rRNA processing (GO:0006364)

Molecular Function:: ribonuclease M5 activity (GO:0043822)

Date:: 2024-07-22

Family Accession:: TIGR00334.1
Method:: HMM

Protein Family Models

Protein Family

Send to:

Links from Protein

Items: 8

Send to:

Supplemental Content

Find related data

Recent activity