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gamma-glutamylcyclotransferase
The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides [1, 2]. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells. [1]. 23070364. Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione. Kumar A, Tikoo S, Maity S, Sengupta S, Sengupta S, Kaur A, Bachhawat AK;. EMBO Rep. 2012;13:1095-1101. [2]. 25716890. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of gamma-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, Kaur A, Chattopadhyay B, Bachhawat AK;. Biochem J. 2015;468:73-85. (from Pfam)
glutathione-specific gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl
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