Protein Family Models

IS66 family insertion sequence element accessory protein TnpB is part of a transposase complex that binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Date:

2024-12-13

This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition [2]. [1]. 10489437. The Sinorhizobium meliloti insertion sequence (IS) element ISRm14 is related to a previously unrecognized IS element located adjacent to the Escherichia coli locus of enterocyte effacement (LEE) pathogenicity island. Schneiker S, Kosier B, Puhler A, Selbitschka W;. Curr Microbiol 1999;39:274-281. [2]. 11418571. Structural and functional characterization of IS679 and IS66-family elements. Han CG, Shiga Y, Tobe T, Sasakawa C, Ohtsubo E;. J Bacteriol 2001;183:4296-4304. (from Pfam)

Gene:

tnpB

Date:

2024-10-16

Date:

2019-09-10

Date:

2019-09-10

The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.

Gene:

tnpB

Date:

2021-05-14