Protein Family Models

YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon [1,2]. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, Pfam:PF02604. [1]. 17263853. Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module. Motiejunaite R, Armalyte J, Markuckas A, Suziedeliene E;. FEMS Microbiol Lett. 2007;268:112-119. [2]. 19210620. Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Prysak MH, Mozdzierz CJ, Cook AM, Zhu L, Zhang Y, Inouye M, Woychik NA;. Mol Microbiol. 2009;71:1071-1087. [3]. 19707553. A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. Kolodkin-Gal I, Verdiger R, Shlosberg-Fedida A, Engelberg-Kulka H;. PLoS One. 2009;4:e6785. (from Pfam)

Date:

2024-10-16

type II toxin-antitoxin (TA) system YafQ family toxin similar to Escherichia coli YafQ, which functions as a sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis, and is the toxin component of the YafQ-DinJ TA module that plays a role in biofilm formation

Date:

2017-08-03

YafQ is the toxin partner to DinJ in a type II toxin-antitoxin system. YafQ is an mRNA interferase, while DinJ is both a transcriptional repressor and a YafQ-binding protein.

Gene:

yafQ

Date:

2021-02-10

Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE.

Date:

2019-09-10

This HMM represents a cluster of eubacterial proteins and a cluster of archaeal proteins, all of which are uncharacterized, from 85 to 102 residues in length, and similar in sequence. These include YafQ, a ribosome-associated endoribonuclease that serves as part of a toxin-antitoxin system, for which DinJ is the antidote component.

Date:

2021-04-27