Protein Family Models

Date:

2024-08-14

L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesised by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide [1,2]. [1]. 12057193. Variation on a Theme of SDR. dTDP-6-Deoxy-L- lyxo-4-Hexulose. Reductase (RmlD) Shows a New Mg(2+)-Dependent Dimerization Mode.. Blankenfeldt W, Kerr ID, Giraud MF, McMiken HJ, Leonard G,. Whitfield C, Messner P, Graninger M, Naismith JH;. Structure (Camb) 2002;10:773-786.. [2]. 10802738. RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new. class of epimerase.. Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH;. Nat Struct Biol 2000;7:398-402. (from Pfam)

Date:

2024-08-14

This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose. 4-epimerase from Escherichia coli.. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden. HM;. Biochemistry 1997;36:6294-6304. (from Pfam)

Date:

2024-08-14

The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerisation of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones. [1]. 1562516. Structure and tissue-specific expression of 3. beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in. human and rat classical and peripheral steroidogenic tissues.. Labrie F, Simard J, Luu-The V, Pelletier G, Belanger A, Lachance. Y, Zhao HF, Labrie C, Breton N, de Launoit Y, et al. J Steroid Biochem Mol Biol 1992;41:421-435. (from Pfam)

Date:

2024-08-14

This family consists of examples of ADP-L-glycero-D-mannoheptose-6-epimerase, an enzyme involved in biosynthesis of the inner core of lipopolysaccharide (LPS) for Gram-negative bacteria. This enzyme is homologous to UDP-glucose 4-epimerase (TIGR01179) and belongs to the NAD dependent epimerase/dehydratase family (PF01370).

Gene:

rfaD

Date:

2024-05-28

ADP-glyceromanno-heptose 6-epimerase catalyzes the NAD-dependent interconversion of ADP-D-glycero-D-mannoheptose and ADP-L-glycero-D-mannoheptose in the lipopolysaccharide core biosynthesis pathway

Date:

2018-06-28

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose

Gene:

rfaD

Date:

2021-08-26