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CrcB family protein
CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance [1,2]. [1]. 8844142. Overproduction of three genes leads to camphor resistance and. chromosome condensation in Escherichia coli.. Hu KH, Liu E, Dean K, Gingras M, DeGraff W, Trun NJ;. Genetics 1996;143:1521-1532.. [2]. 12904550. Phenotypic characterization of overexpression or deletion of the. Escherichia coli crcA, cspE and crcB genes.. Sand O, Gingras M, Beck N, Hall C, Trun N;. Microbiology. 2003;149:2107-2117. (from Pfam)
fluoride efflux transporter CrcB
fluoride efflux transporter CrcB is important for reducing fluoride concentration in the cell, thus reducing its toxicity
CrcB was previously annotated as camphor resistance protein, and linked to chromosome condensation. However, it confers resistance to fluoride ion, by acting as an efflux transporter, and usually is preceded by a fluoride-responsive riboswitch.
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