Protein Family Models

SafA is a bacterial transmembrane protein family that connects the signal transduction between the two component systems EvgS/EvgA and PhoQ/Phop. SafA interacts with PhoQ, leading to the PhoQ/PhoP system activation in response to acid stress conditions [1]. [1]. 17998538. B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Eguchi Y, Itou J, Yamane M, Demizu R, Yamato F, Okada A, Mori H, Kato A, Utsumi R;. Proc Natl Acad Sci U S A. 2007;104:18712-18717. (from Pfam)

Gene:

safA

Date:

2024-10-16

two-component system connector SafA connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions

Date:

2020-08-24

The small membrane protein SafA (66 amino acids in Escherichia coli K-12) is induced by the EvgS/EvgA two-component system (TCS). Because it then activates the PhoQ/PhoP TCS, by direct interaction with the sensor PhoQ, it is called a connector between those two systems.

Gene:

safA

Date:

2020-09-11