Protein Family Models

This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller [1]. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane. [1]. 10348868. Function of proline residues of MotA in torque generation by the flagellar motor of Escherichia coli. Braun TF, Poulson S, Gully JB, Empey JC, Van Way S, Putnam A, Blair DF;. J Bacteriol 1999;181:3542-3551. [2]. 9811664. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. Higgs PI, Myers PS, Postle K;. J Bacteriol 1998;180:6031-6038. (from Pfam)

Date:

2024-10-16

Gene:

exbB

Date:

2021-10-28

biopolymer transporter ExbBis involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates

Date:

2018-09-10

This model describes ExbB proteins, part of the MotA/TolQ/ExbB protein family. The paired proteins MotA and MotB, TolQ and TolR, and ExbB and ExbD harness the proton-motive force to drive the flagellar motor, energize the Tol-Pal system, or energize TonB, respectively. Tol-Pal and TonB are both active at the outer membrane. Genomes may have many different TonB-dependent receptors, of which many of those characterized are involved in siderophore transport across the outer membrane.

Gene:

exbB

Date:

2024-06-26