Protein Family Models

The D-amino acid transferases (D-AAT) are required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity. Crystal structure. [1]. 7626635. Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity. Sugio S, Petsko GA, Manning JM, Soda K, Ringe D;. Biochemistry 1995;34:9661-9669. [2]. 9163511. Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 A resolution. Okada K, Hirotsu K, Sato M, Hayashi H, Kagamiyama H;. J Biochem 1997;121:637-641. (from Pfam)

Date:

2024-10-16

Members of this protein family are aminodeoxychorismate lyase (ADC lyase), EC 4.1.3.38, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (PF01063).

Gene:

pabC

Date:

2024-06-21

aminodeoxychorismate lyase catalyzes the production of 4-aminobenzoate (PABA) from 4-amino-4-deoxychorismate in folate biosynthesis pathway

Date:

2023-03-07

Catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate

Gene:

pabC

Date:

2021-08-24