Protein Family Models

This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3]. [1]. 15223314. Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X;. J Mol Biol. 2004;340:695-706. [2]. 16364916. Molecular basis for bacterial class I release factor methylation by PrmC. Graille M, Heurgue-Hamard V, Champ S, Mora L, Scrima N, Ulryck N, van Tilbeurgh H, Buckingham RH;. Mol Cell. 2005;20:917-927. [3]. 12741815. Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase. Schubert HL, Phillips JD, Hill CP;. Biochemistry. 2003;42:5592-5599. [4]. 18247349. A novel mode of dimerization via formation of a glutamate anhydride crosslink in a protein crystal structure. Agarwal R, Burley SK, Swaminathan S;. Proteins. 2008;71:1038-1041. (from Pfam)

Date:

2024-10-16

This family appears to have methyltransferase activity. (from Pfam)

Date:

2024-08-14

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

Methyltrans_16 is a lysine methyltransferase. Characterised members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins [2,3,4,5]. [1]. 12872006. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, Dlakic M, Clarke S;. Mol Cell Proteomics 2003;2:525-540. [2]. 20975703. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Magnani R, Dirk LM, Trievel RC, Houtz RL;. Nat Commun. 2010;1:43. [3]. 22948820. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, Davydova E, Jakobsson M, Moen A, Pettersen S, Maelandsmo GM, Egge-Jacobsen W, Falnes PO;. Nat Commun. 2012;3:1038. [4]. 23349634. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M, Coulombe B;. PLoS Genet. 2013;9:e1003210. [5]. 23921388. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PO;. J Biol Chem. 2013;288:27752-27763. (from Pfam)

Date:

2024-10-16

Members of this family are SAM dependent methyltransferases. (from Pfam)

Date:

2024-08-14

This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. [1]. 8226664. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. Vanet A, Plumbridge JA, Alix JH;. J Bacteriol 1993;175:7178-7188. (from Pfam)

Date:

2024-10-16

This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14