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DNA-3-methyladenine glycosylase I
The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA. [1]. 8502545. Excision of 3-methylguanine from alkylated DNA by 3-methyladenine DNA glycosylase I of Escherichia coli. Bjelland S, Bjoras M, Seeberg E;. Nucleic Acids Res 1993;21:2045-2049. (from Pfam)
Constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
DNA-3-methyladenine glycosylase I catalyzes hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions
All proteins in this family are alkylation DNA glycosylases that function in base excision repair This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
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