Protein Family Models

Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase [1]. The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4 [2]. This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins. Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria [3]. PQQC has been found to be required in the synthesis of PQQ but its function is unclear. The exact molecular function of members of this family is uncertain. [1]. 1898926. Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis. Pang AS, Nathoo S, Wong SL;. J Bacteriol 1991;173:46-54. [2]. 8662211. Molecular cloning of thi-4, a gene necessary for the biosynthesis of thiamine in Neurospora crassa. Akiyama M, Nakashima H;. Curr Genet 1996;30:62-67. [3]. 12437981. PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone. Toyama H, Fukumoto H, Saeki M, Matsushita K, Adachi O, Lidstrom ME;. Biochem Biophys Res Commun 2002;299:268-272. (from Pfam)

Date:

2024-10-16

The TenA protein of Bacillus subtilis and Staphylococcus aurues, and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae, perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterization as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system (see TIGR02111), heme oxygenase (PF01126), and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme (see TIGR04305).

Gene:

tenA

Date:

2024-02-27