Protein Family Models

These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk [1]. Pyrococcus horikoshii contain a thermostable de-blocking aminopeptidase member of this family used commercially for N-terminal protein sequencing [2]. [1]. 8535515. A non-essential glutamyl aminopeptidase is required for optimal. growth of Lactococcus lactis MG1363 in milk.. l'Anson KJ, Movahedi S, Griffin HG, Gasson MJ, Mulholland F;. Microbiology 1995;141:2873-2881.. [2]. 11798173. Active site of deblocking aminopeptidase from Pyrococcus. horikoshii.. Onoe S, Ando S, Ataka M, Ishikawa K;. Biochem Biophys Res Commun 2002;290:994-997.. [3]. 10218575. Thermostable aminopeptidase from Pyrococcus horikoshii.. Ando S, Ishikawa K, Ishida H, Kawarabayasi Y, Kikuchi H, Kosugi. Y;. FEBS Lett 1999;447:25-28.. [4]. 11980710. Tetrahedral aminopeptidase: a novel large protease complex from. archaea.. Franzetti B, Schoehn G, Hernandez JF, Jaquinod M, Ruigrok RW,. Zaccai G;. EMBO J 2002;21:2132-2138. (from Pfam)

Date:

2024-08-14

Gene:

ypdE

Date:

2020-10-26

M42 family metallopeptidase is an aminopeptidase similar to Escherichia coli aminopeptidase YpdE that has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate

Date:

2020-10-30