Protein Family Models

MepB family protein similar to Staphylococcus aureus mep operon protein MepB that binds DNA and RNA, with a higher affinity towards RNA and single stranded DNA than towards double stranded DNA, and may play a role in responding to antimicrobials

Date:

2024-02-09

In Staphylococcus aureus MepB is encoded by the MepRAB operon. This operon has been shown to play a role in drug resistance and, although the functions of MepR and MapA are known, there is still little information regarding MepB's function. Structural studies have shown that this protein is structural similar to the PD-(D/E)XK family of endonucleases, although PD-(D/E)XK's catalytic active site residues are not conserved in MepB. MepB binds DNA and RNA, with a higher affinity for RNA and single stranded DNA than for double stranded DNA. The association of MepB with this drug resistance operon suggests that this protein is involved in antimicrobial response, role which is believed to be carried out through its interactions with nucleic acids [1]. [1]. 24501097. Structural characterization of MepB from Staphylococcus aureus reveals homology to endonucleases. Agah S, Poulos S, Banchs C, Faham S;. Protein Sci. 2014;23:594-602. (from Pfam)

Date:

2024-10-16