Protein Family Models for Protein (Select 446161752) - Protein Family Models

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Items: 4

Select item 4138371.

endonuclease/exonuclease/phosphatase family protein

This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710. [1]. 10838565. Functionally unrelated signalling proteins contain a fold. similar to Mg2+-dependent endonucleases.. Dlakic M;. Trends Biochem Sci 2000;25:272-273.. [2]. 7885481. Structure and function of the multifunctional DNA-repair enzyme. exonuclease III.. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA;. Nature 1995;374:381-386.. [3]. 1748997. DNase I-induced DNA conformation. 2 A structure of a DNase. I-octamer complex.. Lahm A, Suck D;. J Mol Biol 1991;222:645-667. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Date:: 2024-08-14

Family Accession:: NF015338.5
Method:: HMM

Select item 3905932.

new record, indexing in progress

Family Accession:

Select item 3495133.

new record, indexing in progress

Family Accession:

Select item 1473274.

sphingomyelin phosphodiesterase

Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins.