Protein Family Models

This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF02775. There are two completely conserved residues (A and G) that may be functionally important. PFO is involved in carbon dioxide fixation via a reductive TCA cycle. It forms a heterodimer (alpha/beta). The beta subunit has binding motifs for Fe-S clusters and thiamine pyrophosphate. [1]. 11401501. The genes for anabolic 2-oxoglutarate: ferredoxin oxidoreductase. from Hydrogenobacter thermophilus TK-6.. Yun NR, Arai H, Ishii M, Igarashi Y;. Biochem Biophys Res Commun. 2001;282:589-594. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of beta subunits, representing mostly pyruvate and 2-ketoisovalerate specific enzymes.

Date:

2019-09-10

2-oxoacid:ferredoxin oxidoreductase subunit beta is a component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA

Date:

2018-03-12