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Links from Protein

Items: 7

1.

aldehyde dehydrogenase family protein

This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity. [1]. 9195888. Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. Steinmetz CG, Xie P, Weiner H, Hurley TD;. Structure 1997;5:701-711. (from Pfam)

GO Terms:
Molecular Function:
oxidoreductase activity (GO:0016491)
Date:
2024-10-16
Family Accession:
NF012398.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.
new record, indexing in progress
Family Accession:
5.

betaine-aldehyde dehydrogenase

Catalyzes the formation of betaine from betaine aldehyde

Gene:
betB
GO Terms:
Molecular Function:
betaine-aldehyde dehydrogenase (NAD+) activity (GO:0008802)
Biological Process:
glycine betaine biosynthetic process from choline (GO:0019285)
Molecular Function:
metal ion binding (GO:0046872)
Date:
2021-07-30
Family Accession:
NF009725.0
Method:
HMM
6.

betaine-aldehyde dehydrogenase

Under osmotic stress, betaine aldehyde dehydrogenase oxidizes glycine betaine aldehyde into the osmoprotectant glycine betaine, via the second of two oxidation steps from exogenously supplied choline or betaine aldehyde. This choline-glycine betaine synthesis pathway can be found in gram-positive and gram-negative bacteria. In Escherichia coli, betaine aldehyde dehydrogenase (betB) is osmotically co-induced with choline dehydrogenase (betA) in the presence of choline. These dehydrogenases are located in a betaine gene cluster with the upstream choline transporter (betT) and transcriptional regulator (betI) [1]. Similar to E.coli, betaine synthesis in Staphylococcus xylosus is also influenced by osmotic stress and the presence of choline with genes localized in a functionally equivalent gene cluster [2]. Organization of the betaine gene cluster in Sinorhizobium meliloti and Bacillus subtilis differs from that of E.coli by the absence of upstream choline transporter and transcriptional regulator homologues [2,3]. Additionally, B.subtilis co-expresses a type II alcohol dehydrogenase with betaine aldehyde dehydrogenase instead of choline dehydrogenase as in E.coli, St.xylosus, and Si.meliloti [3]. Betaine aldehyde dehydrogenase is a member of the aldehyde dehydrogenase family (PF00171).

Gene:
betB
GO Terms:
Molecular Function:
betaine-aldehyde dehydrogenase (NAD+) activity (GO:0008802)
Biological Process:
glycine betaine biosynthetic process from choline (GO:0019285)
Molecular Function:
metal ion binding (GO:0046872)
Date:
2024-06-21
Family Accession:
TIGR01804.1
Method:
HMM
7.

betaine-aldehyde dehydrogenase

betaine-aldehyde dehydrogenase catalyzes the formation of betaine from betaine aldehyde

Date:
2023-03-16
Family Accession:
10014153
Method:
Sparcle
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