Protein Family Models

This presumed domain found in type IV secretion system proteins is functionally uncharacterised. This domain family is found in proteobacteria, and is approximately 170 amino acids in length. The family is found in association with Pfam:PF11130. There are two conserved sequence motifs: GWDL and QGEY. (from Pfam)

Date:

2024-08-14

This entry represents the P-loop domain found in the TraG conjugation protein. (from Pfam)

Date:

2024-08-14

This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process [1]. [1]. 1350587. Localization of TraC, a protein involved in assembly of the F conjugative pilus. Schandel KA, Muller MM, Webster RE;. J Bacteriol. 1992;174:3800-3806. (from Pfam)

Date:

2024-10-16

This entry represents the central domain found in archaeal proteins such as DNA double-strand break repair helicase HerA (EC:3.6.4.12). HerA is a helicase which is able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [1]. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus [2]. This domain includes the the central RecA-like catalytic core and a flanking four-helix bundle [3]. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands. [1]. 14990749. A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea. Constantinesco F, Forterre P, Koonin EV, Aravind L, Elie C;. Nucleic Acids Res. 2004;32:1439-1447. [2]. 25880130. Efficient 5'-3' DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeon Sulfolobus islandicus. Huang Q, Liu L, Liu J, Ni J, She Q, Shen Y;. BMC Mol Biol. 2015;16:2. [3]. 25420454. Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea. Rzechorzek NJ, Blackwood JK, Bray SM, Maman JD, Pellegrini L, Robinson NP;. Nat Commun. 2014;5:5506. (from Pfam)

Date:

2024-10-16

type IV secretion system protein TraC is one of the proteins encoded by the transfer (tra) region of the F pilus assembly Type-IV secretion system for plasmid transfer; is required for the assembly of mature F-pilin subunits into extended F pili

Date:

2018-04-16

The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.

Gene:

traC

Date:

2019-09-10

Gene:

traC

Date:

2020-10-26