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Links from Protein

Items: 9

1.

4Fe-4S cluster-binding domain-containing protein

This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich. (from Pfam)

Date:
2024-08-14
Family Accession:
NF024747.5
Method:
HMM
2.

radical SAM protein

Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. [1]. 11222759. Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Sofia HJ, Chen G, Hetzler BG, Reyes-Spindola JF, Miller NE;. Nucleic Acids Res 2001;29:1097-1106. [2]. 17335281. Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification. Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O;. J Am Chem Soc. 2007;129:3462-3463. [3]. 16766528. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. Berteau O, Guillot A, Benjdia A, Rabot S;. J Biol Chem. 2006;281:22464-22470. (from Pfam)

GO Terms:
Molecular Function:
catalytic activity (GO:0003824)
Molecular Function:
4 iron, 4 sulfur cluster binding (GO:0051539)
Date:
2024-10-16
Family Accession:
NF015983.5
Method:
HMM
3.
new record, indexing in progress
Family Accession:
4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.

pyruvate formate lyase 1-activating protein

pyruvate formate lyase 1-activating protein is a radical SAM protein that activates pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Date:
2018-09-26
Family Accession:
11485227
Method:
Sparcle
8.

pyruvate formate-lyase-activating protein

An iron-sulfur protein with a radical-SAM domain (PF04055). A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase (formate-pyruvate lyase), is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5-yl radical, which then abstracts a hydrogen radical from the glycine residue [1].

Gene:
pflA
GO Terms:
Molecular Function:
[formate-C-acetyltransferase]-activating enzyme activity (GO:0043365)
Date:
2022-01-25
Family Accession:
TIGR02493.1
Method:
HMM
9.

pyruvate formate lyase 1-activating protein

Activates pyruvate formate-lyase 1 under anaerobic conditions

Gene:
pflA
GO Terms:
Molecular Function:
[formate-C-acetyltransferase]-activating enzyme activity (GO:0043365)
Molecular Function:
4 iron, 4 sulfur cluster binding (GO:0051539)
Date:
2021-10-04
Family Accession:
NF008356.0
Method:
HMM

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