Protein Family Models

This entry represents transcriptional regulatory proteins in Staphylococcal species including SarA and Rot [1-5]. Sar is a global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors [5]. Paper describing PDB structure 1hsj. [1]. 11381122. Crystal structure of the SarR protein from Staphylococcus aureus. Liu Y, Manna A, Li R, Martin WE, Murphy RC, Cheung AL, Zhang G;. Proc Natl Acad Sci U S A. 2001;98:6877-6882. Paper describing PDB structure 1p4x. [2]. 12837797. Crystal structure of the SarS protein from Staphylococcus aureus. Li R, Manna AC, Dai S, Cheung AL, Zhang G;. J Bacteriol. 2003;185:4219-4225. Paper describing PDB structure 2fnp. [3]. 16455801. Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Liu Y, Manna AC, Pan CH, Kriksunov IA, Thiel DJ, Cheung AL, Zhang G;. Proc Natl Acad Sci U S A. 2006;103:2392-2397. Paper describing PDB structure 4q77. [4]. 25195759. Structure of Rot, a global regulator of virulence genes in Staphylococcus aureus. Zhu Y, Fan X, Zhang X, Jiang X, Niu L, Teng M, Li X;. Acta Crystallogr D Biol Crystallogr. 2014;70:2467-2476. Paper describing PDB structure 4rbr. [5]. 25331435. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence. Killikelly A, Benson MA, Ohneck EA, Sampson JM, Jakoncic . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-28

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. [1]. 9068629. The Salmonella typhimurium mar locus: molecular and genetic analyses and assessment of its role in virulence. Sulavik MC, Dazer M, Miller PF;. J Bacteriol 1997;179:1857-1866. [2]. 11473263. The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF;. Nat Struct Biol 2001;8:710-714. (from Pfam)

Date:

2024-10-16

This HMM represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by Pfam HMM PF01047.

Date:

2024-05-30

SarV (Staphylococcal accessory regulator V) is a MarR family DNA-binding transcriptional regulator. Unlike some other, longer members of the family, it lacks a tandem duplication.

Gene:

sarV

Date:

2017-12-13