Protein Family Models

GspD is a type II general secretion pathway protein involved in protein export. This is the N0 domain found at the N-terminal of GspD type II secretins and its close homologues [1-5]. These proteins form a dodecameric ring, in which the N0 domain mediate extensive contacts suggesting that dodecameric N0 ring is an important feature of T2SS secretins [4]. This domain is also found in virion export proteins, proteins thought to form a channel across the host outer membrane for the purposes of extruding the bacteriophage. Paper describing PDB structure 3ezj. [1]. 19217396. Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. Korotkov KV, Pardon E, Steyaert J, Hol WG;. Structure. 2009;17:255-265. Paper describing PDB structure 3oss. [2]. 21931548. Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. Korotkov KV, Johnson TL, Jobling MG, Pruneda J, Pardon E, Heroux A, Turley S, Steyaert J, Holmes RK, Sandkvist M, Hol WG;. PLoS Pathog. 2011;7:e1002228. Paper describing PDB structure 4e9j. [3]. 23188826. New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa. Van der Meeren R, Wen Y, Van Gelder P, Tommassen J, Devreese B, Savvides SN;. J Biol Chem. 2013;288:1214-1225. Paper describing PDB structure 4jtm. [4]. 23820381. A dodecameric ring-like structure of the N0 domain of the type II secretin from enterotoxigenic Escherichia coli. Korotkov KV, Delarosa JR, Hol WGJ;. J Struct Biol. 2013;183:354-362. Paper describing PDB structure 5mp2. . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This is a short, often repeated, domain found in bacterial type II/III secretory system proteins. All previous NolW-like domains fall into this family. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

In Gram-negative bacteria, proteins that have first crossed the inner member by Sec-dependent protein transport can be exported across the outer membrane by type II secretion, also called the main terminal branch of the general secretion pathway. Members of this family are general secretion pathway protein D. In Yersinia enterocolitica, a second member of this family is part of a novel second type II secretion system specifically associated with virulence (See PMID:12654803). This family is closely homologous to the type IV pilus outer membrane secretin PilQ (TIGR02515) and to the type III secretion system pore YscC/HrcC (TIGR02516).

Gene:

gspD

Date:

2024-05-30