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Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
ornithine carbamoyltransferase
ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis
Catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily.
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