Protein Family Models

VasI is a family of Gram-negative proteins that form part of the pathogenicity apparatus for bacteria-to-bacteria attack. The exact function of this com[onent is not known [1,2]. [1]. 18289922. Type VI secretion: a beginner's guide. Bingle LE, Bailey CM, Pallen MJ;. Curr Opin Microbiol. 2008;11:3-8. [2]. 22184413. Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo X, Yao Y;. Infect Immun. 2012;80:1243-1251. (from Pfam)

Date:

2024-10-16

Members of this protein family, including VC_A0118 from Vibrio cholerae El Tor N16961, are restricted to a subset of bacteria with the type VI secretion system (T6SS), and are encoded among the type VI-associated pathogenicity islands. However, many species with type VI secretion lack a member of this family. This lack suggests that members of this family are accessory proteins, used in a lineage-specific manner in some versions of T6SS and not core to the apparatus. This HMM previously applied the designation TagO, but VasI appears standard.

Gene:

vasI

Date:

2022-10-27