Protein Family Models

Date:

2024-08-14

This family contains members from all branches of life. The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family [1]. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [1]. [1]. 15156151. Memo mediates ErbB2-driven cell motility. Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A;. Nat Cell Biol. 2004;6:515-522. (from Pfam)

Date:

2024-10-16

Members of this protein family belong to the same domain family as the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility). Members of the present family occur as part of a three gene system with an uncharacterized radical SAM enzyme and a homolog of the mammalian protein AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Memo in humans has protein-protein interaction activity with binding of phosphorylated Try, but members of this family may be active as enzymes, as suggested by homology to a class of nonheme iron dioxygenases.

Gene:

amrB

Date:

2019-09-10

Date:

2020-10-26