Protein Family Models

This motif is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either inhibit the peptidase, so as to prevent its premature activation, or has a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides ([1], [2]). [1]. 12589825. General function of N-terminal propeptide on assisting protein folding and inhibiting catalytic activity based on observations with a chimeric thermolysin-like protease. Tang B, Nirasawa S, Kitaoka M, Marie-Claire C, Hayashi K;. Biochem Biophys Res Commun 2003;301:1093-1098. [2]. 8636020. Specific inhibition of mature fungal serine proteinases and metalloproteinases by their propeptides. Markaryan A, Lee JD, Sirakova TD, Kolattukudy PE;. J Bacteriol 1996;178:2211-2215. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Date:

2024-08-14

M4 family metallopeptidase is a zinc metallopeptidase that contains a HEXXH motif, where the histidines are zinc ligands and the glutamate is an active site residue, preferably cleaving Xaa+Yaa, in which Xaa is a hydrophobic residue and Yaa is Leu, Phe, Ile, or Val

Date:

2024-12-20