Protein Family Models

This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice [1]. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S) [1]. YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein [2]. [1]. 17010160. The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice. Erickson KD, Detweiler CS;. Mol Microbiol. 2006;62:883-894. [2]. 19767429. A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC. Pilonieta MC, Erickson KD, Ernst RK, Detweiler CS;. J Bacteriol. 2009;191:7243-7252. (from Pfam)

Date:

2024-10-16

YdeI/OmpD-associated family protein may play a role in antimicrobial peptide (bacteriocin) resistance; similar to Bacillus subtilis protein YdeI

Date:

2024-11-16