Protein Family Models

The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices. (from Pfam)

Date:

2024-08-14

This is a sensor domain found in solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. It can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. This domain recognises Nicotinate, quidalnate, pyridine-2,5-dicarboxylate and salicylate [1]. [1]. 34424339. A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators. Matilla MA, Velando F, Martin-Mora D, Monteagudo-Cascales E, Krell T;. FEMS Microbiol Rev. 2022;46:fuab043. (from Pfam)

Date:

2024-10-16

ABC transporter substrate-binding protein/permease serves as the initial receptor as well as the transmembrane (TM) component of an ABC transporter complex that facilitates the periplasmic binding protein (PBP)-dependent transport across the membrane bilayer of a variety of substrates including amino acids, peptides, or inorganic ions, among others

Date:

2024-04-19

This HMM represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by PF00528, binding-protein-dependent transport systems inner membrane component.

Date:

2024-06-14