Protein Family Models

This domain has a fibronectin type III-like structure [1]. It is often found in association with Pfam:PF00933 and Pfam:PF01915. Its function is unknown. [1]. 20138890. Structural and functional analyses of beta-glucosidase 3B from Thermotoga neapolitana: a thermostable three-domain representative of glycoside hydrolase 3. Pozzo T, Pasten JL, Karlsson EN, Logan DT;. J Mol Biol. 2010;397:724-739. (from Pfam)

Date:

2024-10-16

This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding. [1]. 15236739. The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules. Rigden DJ, Mello LV, Galperin MY;. Trends Biochem Sci. 2004;29:335-339. (from Pfam)

Date:

2024-10-16

This domain is involved in catalysis and may be involved in binding beta-glucan [1]. This domain is found associated with Pfam:PF00933. [1]. 10368285. Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase. Varghese JN, Hrmova M, Fincher GB;. Structure Fold Des 1999;7:179-190. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

glycoside hydrolase family 3 (GH3) protein catalyzes the hydrolytic removal of nonreducing glycosyl end residues from a broad range of beta-D-glycans and beta-D-glycosides

Date:

2024-11-04