This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg Swiss:Q06430) and core-2 branching enzyme (eg Swiss:Q02742). I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development [1]. Core-2 branching enzyme forms crucial side-chain branches in O-glycans [2]. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus [2]. [1]. 8449405. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Bierhuizen MF, Mattei MG, Fukuda M;. Genes Dev 1993;7:468-478. [2]. 9915862. Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. Yeh JC, Ong E, Fukuda M;. J Biol Chem 1999;274:3215-3221. [3]. 22629278. Plant Glycosyltransferases Beyond CAZy: A Perspective on DUF Families. Hansen SF, Harholt J, Oikawa A, Scheller HV;. Front Plant Sci. 2012;3:59. (from Pfam)
GO Terms:- Cellular Component:
- membrane (GO:0016020)
- Molecular Function:
- glycosyltransferase activity (GO:0016757)
- Date:
- 2024-10-16