Protein Family Models

Family of dextranase (EC 3.2.1.11) and isopullulanase (EC 3.2.1.57). Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers. This domain corresponds to the N-terminal Ig-like fold. (from Pfam)

Date:

2024-08-14

The crystal structures of Dex49A from Penicillium minioluteum [1] and of ATCC9642 isopullulanase from Aspergillus niger [2] include beta-solenoid repeats, sharing structural similarities. This Pfam entry includes a single repeat unit of the repeat regions. [1]. 12962629. Dextranase from Penicillium minioluteum: reaction course, crystal structure, and product complex. Larsson AM, Andersson R, Stahlberg J, Kenne L, Jones TA;. Structure. 2003;11:1111-1121. [2]. 18155243. Crystal structure of Aspergillus niger isopullulanase, a member of glycoside hydrolase family 49. Mizuno M, Koide A, Yamamura A, Akeboshi H, Yoshida H, Kamitori S, Sakano Y, Nishikawa A, Tonozuka T;. J Mol Biol. 2008;376:210-220. (from Pfam)

Date:

2024-10-16

IPU and dextranase repeat unit includes three (or one long and one short) parallel beta-strands [1]. The repeat region as a whole folds into a beta-helix, known as beta-solenoid [2]. [1]. 18155243. Crystal structure of Aspergillus niger isopullulanase, a member of glycoside hydrolase family 49. Mizuno M, Koide A, Yamamura A, Akeboshi H, Yoshida H, Kamitori S, Sakano Y, Nishikawa A, Tonozuka T;. J Mol Biol. 2008;376:210-220. [2]. 17190611. Beta-rolls, beta-helices, and other beta-solenoid proteins. Kajava AV, Steven AC;. Adv Protein Chem. 2006;73:55-96. (from Pfam)

Date:

2024-10-16

Family of dextranase (EC 3.2.1.11) and isopullulanase (EC 3.2.1.57). Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers. This domain corresponds to the C-terminal pectate lyase like domain. (from Pfam)

Date:

2024-08-14