Protein Family Models

This is a family of putative type VI secretion system Rhs element Vgr proteins from Proteobacteria. (from Pfam)

Date:

2024-08-14

Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins. (from Pfam)

Date:

2024-08-14

Family of bacterial and phage baseplate assembly proteins responsible for forming the small spike at the end of the tail or bacterial pathogenic needle-shaft [1]. This entry represents the OB fold part of the structure. This structure contains an unusual extra beta hairpin that forms the foundation of the spike protein's beta helix [3]. [1]. 7483254. Bacteriophage P2: genes involved in baseplate assembly. Haggard-Ljungquist E, Jacobsen E, Rishovd S, Six EW, Nilssen O, Sunshine MG, Lindqvist BH, Kim KJ, Barreiro V, Koonin EV, et al.;. Virology 1995;213:109-121. [2]. 24381728. The rise of the Type VI secretion system. Filloux A;. F1000Prime Rep. 2013;5:52. [3]. 22325780. Phage pierces the host cell membrane with the iron-loaded spike. Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG;. Structure. 2012;20:326-339. (from Pfam)

Date:

2024-10-16

VgrG proteins of bacterial type VI secretion systems (T6SS), Pvc8 of the Photorhabdus virulence cassette, and related proteins of phage baseplate assemblies, all members of this family, share the property of occurring at the tip of cell-puncturing contractile injection systems.

Date:

2024-10-16

VgrG (TssI in the revised nomenclature) is the spike protein at the tip of the apparatus of type VI secretion systems. Members of the VgrG family may have an attached effector domain. Effectors encoded as separate polypeptides are termed cargo effectors, while effectors encoded as a fusion with an apparatus component (VgrG, Hcp, or a PAAR protein) are called specialized.

Gene:

tssI

Date:

2024-08-07

This HMM represents the Vgr family of proteins, associated with some classes of Rhs elements. This model does not include a large octapeptide repeat region, VGXXXXXX, found in the Vgr of Rhs classes G and E.

Gene:

vgrG

Date:

2019-09-10

type VI secretion system Vgr family protein such as type VI secretion system tip protein VgrG, a core component and effector of Type VI secretion systems (T6SSs) that are involved in the pathogenicity of several Gram-negative bacteria

Date:

2024-05-09