Protein Family Models

This domain is found N-terminal in Carboxy-terminal processing protease CtpB and related proteins. This enzyme is involved in signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. This domain contains auto-cleavage site at which it is proteolytically cleaved. The remaining part in the mature enzyme is involved in dimerisation [1]. Paper describing PDB structure 4c2c. [1]. 24243021. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T;. Cell. 2013;155:647-658. (from Pfam)

Date:

2024-10-16

This entry represents the PDZ domain from a wide variety of proteins. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

The serine endopeptidases in this family include C-terminal processing proteases such as the periplasmic protease Prc from Escherichia coli, involved in processing penicillin-binding protein (PBP) 3, and carboxyl-terminal processing protease CtpA from Pseudomonas aeruginosa.

Date:

2024-08-14

PDZ domains are found in diverse signaling proteins. Review article. [1]. 9204764. PDZ domains: targeting signalling molecules to sub-membranous sites. Ponting CP, Phillips C, Davies KE, Blake DJ. Bioessays 1997;19:469-479. [2]. 8674113. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R;. Cell. 1996;85:1067-1076. Extension of PDZ family. [3]. 9041651. Evidence for PDZ domains in bacteria, yeast, and plants. Ponting CP;. Protein Sci 1997;6:464-468. [4]. 19738200. Rapid evolution of functional complexity in a domain family. Ernst A, Sazinsky SL, Hui S, Currell B, Dharsee M, Seshagiri S, Bader GD, Sidhu SS;. Sci Signal. 2009;2:ra50. (from Pfam)

Date:

2024-10-16

S41 family peptidase is a serine endopeptidase similar to Bartonella bacilliformis carboxy-terminal-processing protease that shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, and cleaves at a variable distance from the C-terminus

Date:

2024-07-10

Carboxy-terminal processing proteases (EC 3.4.21.102) have paralogs in some species, and different gene symbols in different lineages, such as prc in Escherichia coli K-12, ctpA, ctpB, and ctpC in Synechocystis sp. PCC 6803, and cptA and ctpB in Bacillus subtilis.

Date:

2023-10-20