Protein Family Models

This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid [1]. These proteins are usually composed of a pair of tandem HotDog domains. This entry represents the C-terminal one of the pair. [1]. 7479856. Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering. Yuan L, Voelker TA, Hawkins DJ;. Proc Natl Acad Sci U S A 1995;92:10639-10643. [2]. 1621095. Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants. Voelker TA, Worrell AC, Anderson L, Bleibaum J, Fan C, Hawkins DJ, Radke SE, Davies HM;. Science 1992;257:72-74. [3]. 15531590. A structural model of the plant acyl-acyl carrier protein thioesterase FatB comprised of two helix/4-stranded sheet domains: The N-terminal domain containing residues that affect specificity, the C-terminal domain containing catalytic residues. Mayer KM, Shanklin J;. J Biol Chem 2004; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid [1]. These proteins are usually composed of a pair of tandem HotDog domains. This entry represents the N-terminal one of the pair. [1]. 7479856. Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering. Yuan L, Voelker TA, Hawkins DJ;. Proc Natl Acad Sci U S A 1995;92:10639-10643. [2]. 1621095. Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants. Voelker TA, Worrell AC, Anderson L, Bleibaum J, Fan C, Hawkins DJ, Radke SE, Davies HM;. Science 1992;257:72-74. [3]. 15531590. A structural model of the plant acyl-acyl carrier protein thioesterase FatB comprised of two helix/4-stranded sheet domains: The N-terminal domain containing residues that affect specificity, the C-terminal domain containing catalytic residues. Mayer KM, Shanklin J;. J Biol Chem 2004; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

acyl-[acyl-carrier-protein] thioesterase plays an essential role in chain termination during de novo fatty acid synthesis by hydrolyzing an acyl group on a fatty acid

Date:

2018-10-02