U.S. flag

An official website of the United States government

Links from Protein

Items: 2

1.

MutS domain V

This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters. [1]. 9722634. Domain organization and functional analysis of Thermus. thermophilus MutS protein [published erratum appears in Nucleic. Acids Res 1998 Oct 15;26(20):following 4789]. Tachiki H, Kato R, Masui R, Hasegawa K, Itakura H, Fukuyama K,. Kuramitsu S;. Nucleic Acids Res 1998;26:4153-4159.. [2]. 8036718. Colon cancer and DNA repair: have mismatches met their match?. Jiricny J;. Trends Genet 1994;10:164-168.. [3]. 8510668. The yeast gene MSH3 defines a new class of eukaryotic MutS. homologues.. New L, Liu K, Crouse GF;. Mol Gen Genet 1993;239:97-108.. [4]. 11048710. Crystal structures of mismatch repair protein MutS and its. complex with a substrate DNA.. Obmolova G, Ban C, Hsieh P, Yang W;. Nature 2000;407:703-710. (from Pfam)

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
mismatch repair (GO:0006298)
Molecular Function:
mismatched DNA binding (GO:0030983)
Date:
2024-08-14
Family Accession:
NF012700.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center
External link. Please review our privacy policy.