Protein Family Models for Protein (Select 2629573146) - Protein Family Models

Select item 4266711.

Rolling Circle replication initiation protein N-terminal domain

This is the N-terminal domain of the Rolling Circle Replication Initiator Protein (Rep) from Geobacillus stearothermophilus. This protein acts on plasmids from family pT181 to initiate replication, recruit a helicase to the site of initiation and terminate replication after DNA synthesis. These proteins possess a unique active site and a catalytically essential metal ion is bound in a distinct manner from other rolling circle Reps [1]. [1]. 26792891. Structures of replication initiation proteins from. staphylococcal antibiotic resistance plasmids reveal protein. asymmetry and flexibility are necessary for replication.. Carr SB, Phillips SE, Thomas CD;. Nucleic Acids Res. 2016;44:2417-2428. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF037191.5
Method:: HMM

Select item 4135172.

replication initiation factor domain-containing protein

Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 (Swiss:O15150) and cerebrin-50 (Swiss:Q16301) [2]. [1]. 2270231. Nucleotide sequence of the rep gene of staphylococcal plasmid. pCW7.. Balson DF, Shaw WV;. Plasmid 1990;24:74-80.. [2]. 7735128. Cerebrin-50, a human cerebrospinal fluid protein whose mRNA is. present in multiple tissues but predominantly expressed in the. lymphoblastoid cells and the brain.. Li AH, Silvestrini B, Leone MG, Giacomelli S, Cheng CY;. Biochem Mol Biol Int 1995;35:135-144. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase activity (GO:0003916)

Biological Process:: DNA replication initiation (GO:0006270)

Date:: 2024-08-14

Family Accession:: NF014537.5
Method:: HMM

Select item 4125443.

helix-turn-helix domain-containing protein

This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1]. [1]. 20196080. The crystal structure of NGO0477 from Neisseria gonorrhoeae. reveals a novel protein fold incorporating a helix-turn-helix. motif.. Ren J, Sainsbury S, Nettleship JE, Saunders NJ, Owens RJ;. Proteins. 2010;78:1798-1802. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013540.5
Method:: HMM

Select item 4034624.