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Penicillin binding protein A dimerisation domain
This domain is found in peptidoglycan D,D-transpeptidase also known as penicillin-binding protein A (PBPA). This domain consists of a four-stranded mixed beta-sheet with three short helices packed on one side [2]. Compared to the N-terminal domains of other class B High Molecular Mass (HMM) PBPs, the NTD of PBPA is relatively small because it contains only the so-called inter-domain linker region [1]. Paper describing PDB structure 3lo7. [1]. 20206184. Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. Fedarovich A, Nicholas RA, Davies C;. J Mol Biol. 2010;398:54-65. Paper describing PDB structure 3un7. [2]. 22365933. The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis. Fedarovich A, Nicholas RA, Davies C;. J Mol Biol. 2012;418:316-330. Paper describing PDB structure 7onn. [3]. 34356681. Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Freischem S, Grimm I, Lopez-Perez A, Willbold D, Klenke B, Vuong C, Dingley AJ, Weiergraber OH;. Biomolecules. 2021; [Epub ahead of print] (from Pfam)
serine hydrolase
This is the catalytic domain of class A beta-lactamases [1]. It is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase. [1]. 19100272. Structure of PBP-A from Thermosynechococcus elongatus, a penicillin-binding protein closely related to class A beta-lactamases. Urbach C, Evrard C, Pudzaitis V, Fastrez J, Soumillion P, Declercq JP;. J Mol Biol. 2009;386:109-120. (from Pfam)
penicillin-binding transpeptidase domain-containing protein
The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family. [1]. 8605631. X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O. Nat Struct Biol 1996;3:284-289. (from Pfam)
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