Protein Family Models for Protein (Select 2590445356) - Protein Family Models

Select item 4234371.

This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2], and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6 [3]. This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288. [1]. 10359639. The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Schalkwijk J, Wiedow O, Hirose S;. Biochem J. 1999;340:569-577. [2]. 12796487. Molecular structure of galactokinase. Thoden JB, Holden HM;. J Biol Chem. 2003;278:33305-33311. [3]. 15526155. Galactokinase: structure, function and role in type II galactosemia. Holden HM, Thoden JB, Timson DJ, Reece RJ;. Cell Mol Life Sci. 2004;61:2471-2484. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF021988.5
Method:: HMM

Select item 4117622.

GHMP kinases N terminal domain

This family includes homoserine kinases, galactokinases and mevalonate kinases. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-08-14

Family Accession:: NF012509.5
Method:: HMM

Select item 3964793.

new record, indexing in progress

Family Accession:

Select item 3882004.

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Family Accession:

Select item 3610645.

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Family Accession:

Select item 3466486.

new record, indexing in progress

Family Accession:

Select item 914207.

galactokinase

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Date:: 2024-12-16

Family Accession:: 11414964
Method:: Sparcle

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