Protein Family Models for Protein (Select 2576001611) - Protein Family Models

Select item 4233671.

topoisomerase C-terminal repeat-containing protein

This domain is repeated up to five times to form the C-terminal region of bacterial topoisomerase immediately downstream of the zinc-finger motif. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024761.5
Method:: HMM

Select item 4135442.

DNA topoisomerase

This HMM identifies a region shared by DNA topoisomerases of different types, including ATP-independent (type I) topoisomerases such as TopA and TopB, and ATP-dependent reverse gyrases.

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase activity (GO:0003916)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2024-10-16

Family Accession:: NF013311.5
Method:: HMM

Select item 4124483.

toprim domain-containing protein

This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks. [1]. 9722641. Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Aravind L, Leipe DD, Koonin EV;. Nucleic Acids Res 1998;26:4205-4213. [2]. 9224947. Cloning and analysis of the dnaG gene encoding Pseudomonas putida DNA primase. Szafranski P, Smith CL, Cantor CR;. Biochim Biophys Acta 1997;1352:243-248. [3]. 8294018. The Haemophilus influenzae dnaG sequence and conserved bacterial primase motifs. Versalovic J, Lupski JR;. Gene 1993;136:281-286. [4]. 9121560. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Bergerat A, de Massy B, Gadelle D, Varoutas PC, Nicolas A, Forterre P;. Nature 1997;386:414-417. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013878.5
Method:: HMM

Select item 4004784.