Protein Family Models

This family appears to be related to the Pfam:PF00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16]. [1]. 8090199. The ancient regulatory-protein family of WD-repeat proteins. Neer EJ, Schmidt CJ, Nambudripad R, Smith TF;. Nature 1994;371:297-300. (from Pfam)

Date:

2024-10-16

This family consists of proteins predominantly found in bacteria, including Alkaline phosphatase PhoX from Pseudomonas fluorescens (Swiss:Q3K5N8), a phosphomonoesterase with no phosphodiesterase activity. This protein adopts a six-bladed beta-propeller fold, with the active site located at the bottom of the cavity at the centre of the propeller [1]. [1]. 25190793. A complex iron-calcium cofactor catalyzing phosphotransfer chemistry. Yong SC, Roversi P, Lillington J, Rodriguez F, Krehenbrink M, Zeldin OB, Garman EF, Lea SM, Berks BC;. Science. 2014;345:1170-1173. (from Pfam)

Date:

2024-10-16