Protein Family Models

This domain is found at the C terminus of protein members of the glycoside hydrolase family 123, including N-acetylgalactosaminidase from Clostridium perfringens. This enzyme removes specific terminal N-D-acetylgalactosamine from glycosphingolipids. This catalytic domain adopts an alpha/beta barrel configuration with a two-stranded beta sheet and a pair of alpha-helices at the C-terminal end [1,2]. [1]. 27038508. The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens. Noach I, Pluvinage B, Laurie C, Abe KT, Alteen MG, Vocadlo DJ, Boraston AB;. J Mol Biol. 2016;428:3253-3265. [2]. 27546776. Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-beta-galactosaminidase that uses neighbouring group participation. Roth C, Petricevic M, John A, Goddard-Borger ED, Davies GJ, Williams SJ;. Chem Commun (Camb). 2016;52:11096-11099. (from Pfam)

Date:

2024-12-16

DUF4091 domain-containing protein similar to Clostridium perfringens beta-N-acetylgalactosaminidase, a glycoside hydrolase from the carbohydrate active enzyme family GH123

Date:

2019-09-09