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Single-stranded DNA-binding protein, Bacteriophage T7
Single-stranded DNA-binding proteins (SSB, also known as helix-destabilising proteins and gp2.5) from Bacteriophage T7 is expressed in the late stage of lytic development, binding binding preferentially to single-stranded DNA and is implicated in DNA replication, formation of concatemers, recombination and repair of double-stranded breaks [1]. It physically interacts with T7 DNA polymerase and T7 primase-helicase during replication to coordinate events at the replication fork [1]. Paper describing PDB structure 1je5. [1]. 11481454. Structure of the gene 2.5 protein, a single-stranded DNA binding protein encoded by bacteriophage T7. Hollis T, Stattel JM, Walther DS, Richardson CC, Ellenberger T;. Proc Natl Acad Sci U S A. 2001;98:9557-9562. (from Pfam)
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