Protein Family Models

This family consists of a series of short proteins of around 90 residues in length. The human protein Swiss:O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) [1]. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues [2]. The function of this family is unknown. [1]. 11920613. bc10: A novel human bladder cancer-associated protein with a conserved genomic structure downregulated in invasive cancer. Gromova I, Gromov P, Celis JE;. Int J Cancer 2002;98:539-546. [2]. 15797904. A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10. Clutterbuck DR, Leroy A, O'Connell MA, Semple CA;. Bioinformatics. 2005;21:2590-2595. (from Pfam)

Date:

2024-10-16

PHA00455 family protein

Date:

2017-03-02