Protein Family Models

This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes [1-3]. It folds into an anti-parallel four-helix bundle and forms homopentamers [4]. [1]. 8341711. Intervening sequence with conserved open reading frame in. eubacterial 23S rRNA genes.. Ralph D, McClelland M;. Proc Natl Acad Sci U S A 1993;90:6864-6868.. [2]. 7751314. Characterization of the 23S and 5S rRNA genes of Coxiella. burnetii and identification of an intervening sequence within. the 23S rRNA gene.. Afseth G, Mo YY, Mallavia LP;. J Bacteriol 1995;177:2946-2949.. [3]. 17644584. The unusual 23S rRNA gene of Coxiella burnetii: two. self-splicing group I introns flank a 34-base-pair exon, and one. element lacks the canonical omegaG.. Raghavan R, Miller SR, Hicks LD, Minnick MF;. J Bacteriol. 2007;189:6572-6579.. [4]. 16948161. Crystal structure of the conserved hypothetical cytosolic. protein Xcc0516 from Xanthomonas campestris reveals a novel. quaternary structure assembled by five four-helix bundles.. Lin LY, Ching CL, Chin KH, Chou SH, Chan NL;. Proteins. 2006;65:783-786. (from Pfam)

Date:

2024-08-14

This family describes a protein of unknown function whose structure is a bundle of four long alpha helices. Some of the first members of this family were found encoded in the (atypically large) intervening sequence (IVS) of Leptospira 23S RNA, a region often present in the rRNA gene and removed during rRNA processing without re-ligation. However, this location is not conserved, so names linking this protein to 23S rRNA can be misleading, and names suggesting members are ribosomal proteins (e.g. ribosomal protein S23) are simply wrong. A related protein, outside the scope of this family, is Avd (the accessory variability determinant) of diversity-generating retroelement (GDR) systems.

Date:

2019-09-10