Protein Family Models

Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2]. The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037). [1]. 2207102. Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H. Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT;. Biochemistry 1990;29:7237-7244. [2]. 10751389. The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases. Baumer S, Ide T, Jacobi C, Johann A, Gottschalk G, Deppenmeier U;. J Biol Chem 2000;275:17968-17973. [3]. 3531194. Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum. Shuber AP, Orr EC, Recny MA, Schendel PF, May HD, Schauer NL, Ferry JG;. J Biol Chem 1986;261:12942-12947. (from Pfam)

Date:

2024-10-16

Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the N termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2]. The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037). [1]. 2207102. Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H. Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT;. Biochemistry 1990;29:7237-7244. [2]. 10751389. The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases. Baumer S, Ide T, Jacobi C, Johann A, Gottschalk G, Deppenmeier U;. J Biol Chem 2000;275:17968-17973. [3]. 3531194. Cloning, expression, and nucleotide sequence of the formate dehydrogenase genes from Methanobacterium formicicum. Shuber AP, Orr EC, Recny MA, Schendel PF, May HD, Schauer NL, Ferry JG;. J Biol Chem 1986;261:12942-12947. (from Pfam)

Date:

2024-10-16