Protein Family Models for Protein (Select 2285177746) - Protein Family Models

Select item 4146421.

transporter associated domain-containing protein

This small domain is found in a family of proteins with the Pfam:PF01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF015436.5
Method:: HMM

Select item 4134202.

TrkA C-terminal domain-containing protein

This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1]. [1]. 11292341. Regulatory potential, phyletic distribution and evolution of. ancient, intracellular small-molecule-binding domains.. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Molecular Function:: monoatomic cation transmembrane transporter activity (GO:0008324)

Date:: 2024-08-14

Family Accession:: NF014171.5
Method:: HMM

Select item 4114013.

cation:proton antiporter

Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. [1]. 9537504. Comparative molecular analysis of Na+/H+ exchangers: a unified. model for Na+/H+ antiport?. Dibrov P, Fliegel L;. FEBS Lett 1998;424:1-5.. [2]. 9278382. Na+/H+ exchangers of mammalian cells.. Orlowski J, Grinstein S;. J Biol Chem 1997;272:22373-22376.. [3]. 9507001. Identification of a mitochondrial Na+/H+ exchanger.. Numata M, Petrecca K, Lake N, Orlowski J;. J Biol Chem 1998;273:6951-6959. (from Pfam)

GO Terms:

Biological Process:: monoatomic cation transport (GO:0006812)

Molecular Function:: antiporter activity (GO:0015297)

Cellular Component:: membrane (GO:0016020)

Biological Process:: transmembrane transport (GO:0055085)

Biological Process:: proton transmembrane transport (GO:1902600)

Date:: 2024-08-14

Family Accession:: NF013188.5
Method:: HMM

Select item 3904604.