Protein Family Models

This presumed domain is functionally uncharacterised. This domain family is predominantly found in Bacteroidetes, and is about 100 amino acids in length. This domain contains a highly conserved YDxxGR motif which suggests that it is related the RHS repeats, that appear to be involved in ligand binding. RHS repeats share structural similarity with the eukaryotic tyrosine-aspartate (YD) repeat [1]. [1]. 23913273. The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Busby JN, Panjikar S, Landsberg MJ, Hurst MR, Lott JS;. Nature. 2013;501:547-550. (from Pfam)

Date:

2024-10-16

This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (PF01839) class, and an RHS repeat (PF05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.

Date:

2023-02-23